News & Updates

  • Fixed issue for miRBase links (09/25/2017);
  • Added support for reducing node overlap for large network layout (09/22/2017);
  • Added Force Atlas layout algorithm to support large network visualization (09/21/2017);
  • Fixed broken links for downloading the mir target data files (08/25/2017);
  • Enhanced data IO for improved performance (06/01/2017);
  • Added support for miRNA family mapping and enrichment analysis (05/09/2017);
  • Fixed bug with lncRNA mapping (05/03/2017);
  • Minor bug fix and performance improvement (03/14/2017);
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Please Cite
Fan Y, Siklenka, K., Arora, SK., Ribeiro, P., Kimmins, S. and Xia, J. (2016) miRNet - dissecting miRNA-target interactions and functional associations through network-based visual analysis. Nucl. Acids Res. 44 W135–141

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Overview

miRNet is an easy-to-use tool with comprehensive support for statistical analysis and functional interpretation of data generated in miRNAs studies. Its main features include:
  • Support for various inputs & statistics: miRNet accepts a list of miRNAs or targets, or a data table from microarray, RNAseq or RT-qPCR experiments. miRNet supports differential analysis using limma, edgeR and HTqPCR methods; enrichment analysis using standard hypergeometric tests and unbiased random sampling.
  • Comprehensive functional annotation: miRNet integrates data from eleven different miRNA databases - TarBase, miRTarBase, miRecords, miRanda (S mansoni only), miR2Disease, HMDD, PhenomiR, SM2miR, PharmacomiR, EpimiR, and starBase. It currently supports nine organisms - Human, Mouse, Rat, Cattle, Chicken, Zebra fish, Fruit fly, C. elegans and S. mansoni.
  • Creation of miRNA-target interaction networks: miRNet provides a wide array of options to allow researchers to build miRNA-target interaction networks at different confidence levels. The resulting network can be further optimized using different algorithms to improve visualization and understanding.
  • High-performance network visual analytics: miRNet offers five types of networks on miRNA-gene, miRNA-disease, miRNA-small molecule, miRNA-lncRNA, and miRNA-epigenetic modifier. The system supports zooming, highlighting, point-and-click, drag-and-drop, enrichment analysis, etc. to enable users to intuitively explore miRNAs, targets and functions.
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