Welcome to miRNet!
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News & Updates
  • Updated R from 3.5.1 to the latest version (3.6.1) (10/16/2019);
  • Added support for pig (429 miRNAs and 8353 genes targets) (10/09/2019);
  • Minor code refactoring for better performance (06/06/2019);
  • Upgraded the web framework to PrimeFaces 7.0 (05/29/2019);
  • Fixed the issue with file uploading (03/11/2019);
  • Fixed the bugs in tissue mapping (03/07/2019);
  • Added two modules to support analysis of xeno-miRNAs (xenomiRs) and their potential targets in different hosts (02/25/2019);
  • Updated the interface for improved performance and better user experience (02/20/2019);
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Key Features
  • Support for various inputs & statistics: miRNet accepts a list of miRNAs or targets, or a data table from microarray, RNAseq or RT-qPCR experiments. miRNet supports differential analysis using limma, edgeR and HTqPCR methods; enrichment analysis using standard hypergeometric tests and unbiased random sampling.
  • Comprehensive functional annotation: miRNet integrates data from eleven different miRNA databases - TarBase, miRTarBase, miRecords, miRanda (S mansoni only), miR2Disease, HMDD, PhenomiR, SM2miR, PharmacomiR, EpimiR, and starBase. It currently supports Human, Mouse, Rat, Cattle, Pig, Chicken, Zebra fish, Fruit fly, C. elegans, and S. mansoni.
  • Exploring xeno-miRNAs and their potential targets: miRNet currently supports six hosts (Human, Mouse, Chicken, Fruit fly, and C. elegans) with xeno-miRNAs reported from over 50 species. It contains over 400 experimentally detected xeno-miRNAs supplemented with 1000 computational predicted transportable miRNAs. Their potential gene targets are predicted using two algorithms - miRanda and TarPmiR.
  • Creation of miRNA-target interaction networks: miRNet provides a wide array of options to allow researchers to build miRNA-target interaction networks at different confidence levels. The resulting network can be further optimized using different algorithms to improve visualization and understanding.
  • High-performance network visual analytics: miRNet offers five types of networks on miRNA-gene, miRNA-disease, miRNA-small molecule, miRNA-lncRNA, and miRNA-epigenetic modifier. The system supports zooming, highlighting, point-and-click, drag-and-drop, enrichment analysis, etc. to enable users to intuitively explore miRNAs, targets and functions.
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